Effect of alkaloids from tripterygium hypoglaucum hutch on apoptosis of human lung adenocarcinoma cell line A549
- VernacularTitle:昆明山海棠总生物碱诱导肺腺癌A549细胞凋亡与细胞周期改变
- Author:
Lebin LIU
- Publication Type:Journal Article
- Keywords:
tripterygium hypoglaucum hutch;
lung adenocarcinoma A549 cell line;
apoptosis;
cell cycle
- From:Journal of Third Military Medical University
1984;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
Objective To explore the mechanism of the alkaloids from tripterygium hypoglaucum hutch(THHa) on the apoptosis of lung cancer.Methods Apoptosis and cell cycle of human lung adenocarcinoma cell line A549 were detected by morphological observation,DNA electrophoresis,and flow cytometry.(Results THHa) could induce apoptosis of human lung adenocarcinoma cell line and arrest the cells at S phase of cell cycle.Conclusion Apoptosis contributes to inhibitory effect of THHa on A549 cells.This may be helpful in designing an appropriate chemotherapeutic regimen in future.
