Effects of cyclophosphamide on proliferation and morphology of human alveolar rhabdomyosarcoma cell xenografted tumor in nude mice
- VernacularTitle:环磷酰胺对人腺泡状横纹肌肉瘤细胞裸鼠移植瘤生长和形态结构的影响
- Author:
Bin LIU
- Publication Type:Journal Article
- Keywords:
cyclophosphamide;
rhabdomyosarcoma;
xenograft;
proliferation;
morphology
- From:Journal of Third Military Medical University
1984;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of cyclophosphamide(CTX) on proliferation and morphology of human alveolar rhabdomyosarcoma cell-line PLA-802 xenografted tumor in nude mice.Methods Sixteen nude mice which had been implanted PLA-802 by subcutaneous injection into the right armpit were divided into control group(5 mice),normal saline group(5 mice) and 20 mg/kg CTX group(6 mice).They were given CTX or normal saline intraperitoneally once every two days,starting on the 7~(th) day after tumor cell transplantation.Tumor volumes were measured every two days for drawing the growth curve.Animals were anesthetized on the 26~(th) day after tumor cell transplantation to get weight and specimens of the tumors.Specimens were stained of HE or EM,and then examined with light microscope and electron microscope.Results The proliferation of xenografted tumors was inhibited significantly(P
