Preparation of chitosan-5-fluorouracil nanometer particle and its drug-release characters
- VernacularTitle:5-FU纳米微粒的制备及其释药特性研究
- Author:
Lu KONG
;
Yangde ZHANG
- Publication Type:Journal Article
- Keywords:
fluorouracil;
chitosan;
sodium alginate;
pharmacokinetics
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare the nanometer particles (NPs) of chitosan-5-fluorouracil (5-FU), and to study its characters of drug release in vivo. Methods Cross-linking polymer technique was employed to prepare the chitosan-5-FU NPs, and their characters were detected by scanning electron microscope and photon correlation spectroscope (PCS); the loaded capacity was measured by ultraviolet spectrophotometry; high-performance liquid chromatography was used to detect the characters of drug release in vivo. Results The chitosan-5-FU-NPs were found to be round or elliptic in shape, with 120 to 150nm in diameter and having a good dispersive ability. The loaded capacity was 31.000%?0.001%. The blood concentration of 5-FU was controlled at 76?g/L, and it was maintained for 48h. Conclusion As a vehicle, chitosan-5-FU NPs can change the behavior of pharmacokinetics and prolong the cycle time of 5-FU in vivo. Chitosan-5-FU NPs ran reduce the initial burst and prolong the releasing time.
