Determination and Significance of Telomerase Activation in Different Parts of Colorectal Canceration Adenoma
- VernacularTitle:大肠恶变性腺瘤不同部位端粒酶活性测定意义
- Author:
Jinying ZHENG
;
Zhonglin NI
;
Jianmin LI
;
Kairong HUANG
- Publication Type:Journal Article
- Keywords:
Telomerase;
Colorectal adenoma;
Adenoma canceration
- From:
Journal of Medical Research
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore relationship between telomerase and canceration of colorectal adenoma.Methods Telomerase activity was measured by hybridization-in-situ in 30 colorectal adenoma,30 normal colorectal mucosa ,30 colorectal adenoma canceration tissues and normal close adenoma.Results The expression of telomerase in colorectal adenoma canceration was 86.6%(strong positive 73.3%, weak positive 13.3%);60% in close adenoma tissues(strong positive 6.7%, weak positive 53.3%),10% in normal colorectal adenoma(strong positive 3.3%, weak positive6.7%),0% in normal colorectal mucosa.Conclusions Telomerase plays a critical role in colorectal adenoma canceration and is a internal factor.It is a sign of canceration tendency(not malignant transformation) in canceration.
