Detection of Neuron-specific Enolase and Soluble Intercellar Adhesion Molecule-1 in Serum and Cerebrospinal Fluid in the Patients with Viral Encephalitis
- VernacularTitle:病毒性脑炎患者NSE和SICAM-1检测临床意义
- Author:
Ning SHI
;
Weijing QIN
;
Hengchao GE
;
Huigang ZHANG
;
Shimei ZHANG
;
Jiaping WANG
- Publication Type:Journal Article
- Keywords:
Viral;
Encephalitis neuron-specific enolase;
Soluble intercellar adhesion molecule-1
- From:
Journal of Medical Research
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of the neuron-specific enolase(NSE) and soluble intercellar adhesion molecule-1(CAM-1) in serum and cerebrospinal fluid(CSF) in the patients with viral encephhalites (VE). Methods The levels of NSE and sICAM-1 in serum and CSF were determined before and after treatment using ELISA in 58 patients with VE and 20 normal persons. Results The levels of NSE and sICAM-1 in serum before treatment were obviously higher than those of control group, and their differences were significant (P0.05). Conclusions NSE and sICAM-1 may contribute to pathologic course in infection of VE and the levels of NSE and sICAM-1 in serum and CSF may serve as markers of differential diagnosis and clinical significance.
