ASSOCIATION OF OSTEOCAICIN GENE POLYMORPHISM WITH BONE MASS IN CHINESE PREMENARCHE GIRLS
- VernacularTitle:青春前期女童骨钙素基因多态性与骨量的相关关系
- Author:
Xincai XIAO
;
Yixiang SU
;
Xiaolin LUO
- Publication Type:Journal Article
- Keywords:
osteocalcin;
gene polymorphism;
BMD;
BMC
- From:
Acta Nutrimenta Sinica
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the proportion of genotypes of osteocalcin gene polymorphism, and to investigate if the polymorphism of osteocalcin gene is associated with BMD in Chinese premenarche girls. Methods: 152 healthy premenarche girls of Han ethic (9-11.5y) were recruited. BMD and BMC at the lumber spine (L1-L4), proximal femur, and total body were measured by DXA; PCR-RFLP was used to amplify the polymorphisms of the osteocalcin gene. Results:The proportion of genotype of OC gene polymorphism were 5.26% HH,, 36.84% Hh, and 58.90% hh, respectively. Significant differences were observed in BMD and BMC at the total body, and BMD at the L1-L4 lumber spine and femur neck among subjects with different genotypes (P
