THE PROTECTIVE EFFECTS OF COLLAGEN PEPTIDE-CHROMIUM(Ⅲ) COMPLEX ON ALLOXAN-INDUCED HEPATIC INJURY IN MICE
- VernacularTitle:胶原蛋白多肽-铬(Ⅲ)螯合物对四氧嘧啶致小鼠肝脏损伤的保护作用
- Author:
Anjun LIU
;
Xiuli WANG
;
Ying CHEN
;
Guorong ZHANG
- Publication Type:Journal Article
- Keywords:
collagen peptide-chromium( Ⅲ ) complex;
alloxan;
hepatic injury
- From:
Acta Nutrimenta Sinica
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the protective effects of collagen peptide-chromium (Ⅲ) complex (CPCC) on alloxan-induced hepatic injury in mice. Method:The mice were divided into three groups (normal, model, CPCC) and given (po.) water, water and CPCC (Cr3+40?g/kg?d) respectively once a day. After 4 weeks, the model and CPCC groups were injected with alloxan. Then the levels of liver index, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) were measured. Activities of superoxide dismutase (SOD) ,glutathione peroxidase (GSH-Px) and contents of malondialdehyde (MDA) in liver were tested. Also liver pathological changes were observed. Results:CPCC could reduce the levels of liver index, serum levels of AST,ALT and ALP as well as contents of MDA and activities of SOD and GSH-Px in liver. Hepatocytes lesion was alleviated markedly. Conclusion:CPCC has protective effects on alloxan-induced hepatic injury in mice.
