Effects of spironolactone on reversing myocardial remodeling and improving cardiac function in CHF patients
- VernacularTitle:螺内酯对充血性心力衰竭患者心室重塑及心功能影响的研究
- Author:
Jianfei WANG
;
Tiaode LI
- Publication Type:Journal Article
- Keywords:
Spironolactone;
Heart failure,congestive;
Myocardial remodeling
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of reversing myocardial remodeling and improving cardiac function in CHF patients with lotensin or lotensin and different doses of spironolactone.Methods Ninety patients were randomized to three groups,respectively lotensin,lotensin with 20mg spironolactone and lotensin with 40mg spironolactone.TNF?,Ald,AngⅡ,LA,LVEDD,LVEDV and EF were measured before and after 12 weeks treatment.Results(1)There were significant decreases in the level of TNF-?,Ald,AngⅡ,LA,LVEDD,LVEDV after treatment compared with before in three groups(P
