Relationship of hypoxia inducible factor-1? expression and microvessel density with biological behavior of hepatocellular carcinoma
- VernacularTitle:缺氧诱导因子-1?表达和肿瘤微血管生成与肝细胞癌生物学行为的关系探讨
- Author:
Lei GAO
;
Junhong MENG
;
Shulan LEI
- Publication Type:Journal Article
- Keywords:
Carcinoma,heptocellular;
Hypoxia inducible factor 1?;
Microvessel density
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of hypoxia inducible factor-1?(HIF-1?) expreesion and microvessel density with biological behavior of hepatocellular carcinoma(HCC).Methods The expreesions of HIF-1? and MVD were studied through immunohistochemistry in 36 cases of hepatocellular carcinoma tissues and 15 cases of paraneoplastic tissues.The relationship between these parameters were analyzed.Results The expression level of HIF-1? and MVD were more significant in HCC tissues than those in paraneoplastic tissues(P
