Research advances in pharmacogenomics of warfarin
- VernacularTitle:华法林的基因组学研究进展
- Author:
Jian YANG
;
Liyan MIAO
- Publication Type:Journal Article
- Keywords:
warfarin;
pharmacogenomics;
gene polymorphism
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Warfarin is widely used as one of the coumarins anticoagulation drugs in the clinical.Every physician has been disturbed by its narrow therapic index and bleeding complications.It is a difficult thing for the doctor to use it rationally.However,recently,with the rapid development of molecule biology,some research find that gene polymorphism of pharmacodynamics and pharmacokinetics cause the individual variability in drug response.In this review,we focus on the latest development in pharmacogenomics of warfarin at home and abroad in order to give some suggestions for the individual use of warfarin.
