Protective effects of nimodipine liposomes for injection on injuries of total cerebral ischemia/reperfusion in rats and anoxia in mice
- VernacularTitle:注射用尼莫地平脂质体对大鼠全脑缺血再灌注和小鼠缺氧性损伤的保护作用
- Author:
Juan YANG
;
Qiujuan WANG
;
Zhiwei PAN
;
Jiabi ZHU
- Publication Type:Journal Article
- Keywords:
nimodipine liposomes for injection;
four-vessel occlusion;
cerebral ischemia/reperfusion;
cerebral anoxia;
Evans blue
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the protective effects of nimodipine liposomes for injection (NDLI) on injuries of total cerebral ischemia/reperfusion(I/R) in rats and anoxia in mice. METHODS: Acute anoxia in mice was produced by hypoxia under normal pressure and decapitation. In these two models the survival time and persistent time of gasping were observed. Ameliorated pulsinelli four-vessel occlusion method was used to make global brain ischemia model. The EEG, the time of righting reflex recovery and Evans blue content in the homogenate of the brain tissues were recorded. RESULTS: NDLI obviously prolonged the survival time and persistent time of gasping in mice subjected to acute anoxia, remarkably shortened the time of EEG recovery and righting reflex recovery, and reduced Evens blue content in the homogenate. CONCLUSION: NDLI has significantly protective effects on injuries of total cerebral I/R and anoxia.
