Relationship between electrophysiologic and pathologic changes in diabetic peripheral neuropathy rats
- VernacularTitle:糖尿病大鼠周围神经病变时神经电生理及病理变化的关系
- Author:
Guiping WANG
;
Hui ZHOU
;
Ying ZHAO
;
Zhimi LIU
- Publication Type:Journal Article
- Keywords:
diabetic neuropathies;
peripheral nervous diseases;
neural conduction;
pathology
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between electrophysiology and pathology changes in diabetic peripheral neuropathy (DPN) rats and to assess the value of electrophysiology in diagnosis of DPN. Methods: Twenty-four healthy male SD rats were intraperitoneally injected with a single dose of streptozotocin to induce DPN models and the rats were subsequently divided into 3 groups, namely, the DPN model group, the low dose Tong-Luo composite recipe (TLCR) group, and the high dose TLCR group. Rats in the latter 2 groups were lavaged with 2 ml double-distilled water containing 0.5 g/kg and 2 g/kg TLCR for 8 weeks, respectively. Antother 8 healthy rats were taken as normal controls. The motor conduction velocity (MCV), sensory conduction velocity (SCV), and potential latency and amplitude of caudal nerves were measured after 8 weeks in all rats. Morphometric quantitative analysis was also performed. Results: Compared with normal control group, the MCV, SCV, and potential amplitude of the caudal nerve in DPN model group were decreased, but the potential latency was increased. After TLCR treatment, the above indices were significantly improved and were close to those of the normal control group. SCV of the low dosage group was still significantly lower than that of normal control group (P
