Preparation and characterization of magnetic poly D,L-lactide-co-glycolide phenylarsine oxide nanoparticles
- VernacularTitle:磁性聚乳酸-羟基乙酸氧化酚砷纳米微粒的制备及其特性
- Author:
Qin DONG
;
Hongpei CAI
;
Zhongbing ZHANG
;
She GAO
- Publication Type:Journal Article
- Keywords:
phenylarsine oxide;
poly D, L-lactic-co-glycolic acid;
magnetite;
nanoparticle
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the preparation technique for magnetic poly D,L-lactide-co-glycolide phenylarsine oxide nanoparticles (M-PLGA-PAO-NPs) and to characterize the resultant product. Methods: M-PLGA-PAO-NPs were prepared by using emulsion-evaporation process. The morphology of the prepared nanoparticles were observed by transmission electron microscope and the magnetism of the particles was determined by vibrating sample magnetometer. Meanwhile, we also evaluated the mean diameter, encapsulation ratio, and drug loading rate of the particles. Results: The nanoparticles had a regular spherical surface, with 80% of them having a diameter of 140-500 nm. We also found that the drug loading rate of the particles was 3.2% and the mean encapsulation ratio was 34.2%. The drug had satisfactory magnetic property. Conclusion: Our method can obtain M-PLGA-PAO-NP with satisfactory quality, it is simple-to-use and the prepared particles can meet the requirement of pharmaceutics.
