Role of angiotensin-Ⅱ in cell apoptosis
- VernacularTitle:血管紧张素-Ⅱ在细胞凋亡中的作用
- Author:
Lijuan YANG
;
Yiming MU
- Publication Type:Journal Article
- Keywords:
angiotensin Ⅱ;
apoptosis;
angiotensin-converting enzyme inhibitors;
angiotensin Ⅱ type 1 receptor blockers
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Angiotensin-Ⅱ-induced apoptosis was widely involved in the pathogenesis of diabetes mellitus, cardiovascular diseases, etc. The mechanism of angiotensin-Ⅱ-induced apoptosis is complicated, including the receptor (AT1R and AT2R) level regulation, Fas/FasL pathway, and the regulation by p53 family, Bcl-2 family, Caspase family, Ang-(1-7), etc. Mitochondria damage and oxidative damage play important roles in the apoptosis process. This article reviews the previous researches on angiotensin-Ⅱ-induced apoptosis.
