Signal transduction in trialkyltin compounds-induced tumor cell apoptosis mechanism trialkyltin compounds-induced tumor cell apoptosis
- VernacularTitle:三烃基锡化合物诱导肿瘤细胞内信号转导的凋亡机制研究进展
- Author:
Huijun LI
;
Xiaoliang ZHENG
;
Xueli LIU
;
Boch QIAN
- Publication Type:Journal Article
- Keywords:
tumor cell;
apoptosis;
trialkyltin compounds;
tributyltin;
triphenyltin;
trimethyltin
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim Organotin compounds are important organometallic chemicals with a variety of technical applications.Of these compounds,the trialkyltins,especially tributyltin,triphenyltin and trimethyltin,have been proved to have the distinct ability to induce tumor cell apoptosis and significant antitumor activity.They can induce tumor cell apoptosis through Fas receptor,mitochondrial,Ca 2+,MAPKs,p53,NF-?B and caspase/p38/ROS pathway.This paper reviewed recent progress in the studies on signal transduction in tumor cell apoptosis induced by trialkyltin compounds.
