Erythropoietin and neuron apoptosis:Signal pathway
- VernacularTitle:促红细胞生成素抗神经元凋亡的信号传导通路
- Author:
Zhikun SUN
;
Shengdi CHEN
- Publication Type:Journal Article
- Keywords:
apoptosis;
erythropoietin;
signal transduction pathways
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Apoptosis is a main death pattern in many nervous system disease.Erythropoietin(Epo)has been originally characterized as the principal regulator of erythropoiesis by stimulating the proliferation and differentiation of erythroid precursor cells.In recent years,many experimental studies have shown that both Epo and EpoR(erythropoietin receptor)are functionally expressed in the nervous system and that this cytokine exerts a remarkable neuroprotection against nerve cell apoptosis.This article reviews neuroprotective of Epo against apoptosis and outline the involved molecular mechanisms.
