Phosphorylation of cAMP response element binding protein in glioma cells induced by bradykinin
- VernacularTitle:缓激肽诱导胶质瘤细胞内cAMP反应元件结合蛋白磷酸化的实验研究
- Author:
Zhenhua WANG
;
Yixue XUE
;
Libo LIU
;
Ping WANG
- Publication Type:Journal Article
- Keywords:
glioma;
bradykinin;
cAMP response element binding protein
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the activation of transcription factor cAMP response element binding protein(CREB)in the rat C6 glioma cells induced by bradykinin,and discuss its possible significance.Methods Immunocytochemistry and western-blot method were used to determine the phosphorylation of CREB after stimulated by 1 ?mol? L-1 bradykinin at various time points(0,5,10,15,20,30min).Results Bradykinin at 1 ?mol? L-1 induced phosphorylation of CREB inthe glioma cells at the indicated time points(0～30min)(P
