Establishment and influencing factors of type Ⅱ collagen induced murine arthritis model
- VernacularTitle:Ⅱ型胶原诱导的小鼠关节炎动物模型的建立及影响因素
- Author:
Ru ZHOU
;
Yifu YANG
;
Jianping ZUO
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
collagen;
murine arthritis
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis(RA)is a serious autoimmune disease.Type Ⅱ collagen induced murine arthritis(CIA)displays polyarthritis and causes chronic and destructive joint damages,which is similar to RA in many aspects.CIA is widely used for the research on RA pathogenesis and drug discovery.In this review,we discussed the establishment of CIA and the key factors participating in the CIA pathogenesis.
