Vasorelaxant effect of sulfur dioxide derivatives on isolated aortic rings of rats and its mechanisms
- VernacularTitle:二氧化硫衍生物舒张大鼠离体主动脉血管环的效应及其机制研究
- Author:
Shuxu DU
;
Chunyu ZHANG
;
Hongfang JIN
;
Junbao DU
- Publication Type:Journal Article
- Keywords:
Sulfur dioxide;
Vasodilation;
Muscle,smooth,vasular;
Rats
- From:
Journal of Peking University(Health Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
6(mmol/L).) Nicardipine(1?10~(-9) mol/L) could decrease the contraction of the rings to NE,and even could inhibit the relaxation of Na_2SO_3/NaHSO_3 almost completely.The inhibition of the endogenous SO_2 production with HDX(1?10~(-4) mol/L),resulted in an increase in the contraction of rings.The contraction curve to NE shifted to the left,and IC_(50) also changed from(6.48?0.84)?10~(-7)mol/L to(3.97?(1.63))?10~(-7) mol/L(P
