Effect of hypoxia on the neurons expression of P2X receptors in CA1 subfield of rat hippocampus
- VernacularTitle:低压缺氧对大鼠海马CA1区神经元P2X受体表达的影响
- Author:
Yandong ZHAO
;
Saiyu CHENG
;
Jinhai ZHANG
;
Huaizhen RUAN
- Publication Type:Journal Article
- Keywords:
hypoxia;
P2X receptor;
hippocampus;
immunohistochemistry
- From:Journal of Third Military Medical University
2003;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of P2X receptors in CA1 subfield of rat hippocampus and the effect of hypoxia on the expression. Methods We set up the hypoxia animal model of high altitude and observed the expression of P2X receptors by using immunohistochemical staining before and after hypoxia. Results Immunohistochemistry showed that there were several sub-type of P2X receptors expressed in hippocampus CA1 neurons. After long term hypoxia, the expression of these receptors was increased. Conclusion there were abundant of P2X receptors expressed on the hippocampus CA1 neurons. Hypoxia affects the expression P2X receptors.
