Effect of CTLA-4Ig on BAEP and SEP in rats of experimental autoimmune encephalomyelitis
- VernacularTitle:CTLA-4Ig对大鼠实验性自身免疫性脑脊髓炎的BAEP、SEP的影响
- Author:
Xingmei ZHANG
;
Jianfeng LU
;
Heqing HUANG
;
Kangning CHEN
- Publication Type:Journal Article
- Keywords:
multiple sclerosis;
experimental autoimmune encephalomyelitis;
CTLA-4Ig;
brain-stem auditory evoked potential;
somatosensory evoked potential
- From:Journal of Third Military Medical University
2003;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the curative effect and safety of CTLA-4Ig transgene for experimental autoimmune encephalomyelitis (EAE). Methods The adenovirus loaded CTLA-4Ig was injected into Wistar rat EAE models through the lateral cerebral ventricle. The clinical symptomatic and electrophysiological changes were observed to judge the efficiency of CTLA-4Ig. Results After injection of AdCTLA-4Ig into the lateral cerebral ventricle of Wistar rat EAE models, the time of EAE onset was delayed and the incidence rate was significantly reduced. And the transductive function tested by brain-stem auditory evoked potential (BAEP) and somatosensory evoked potential (SEP) was obviously improved. Conclusion CTLA-4Ig is effective in managing EAE.
