The heterogeneity between adult and adolescent type 1 diabetes.
- VernacularTitle:青少年与成人期发病的1型糖尿病异质性研究
- Author:
Lili CHEN
;
Hongyan PAN
;
Qiang LI
- Publication Type:Journal Article
- Keywords:
Type 1 diabetes;
HLA;
Autoantibodies to glutamic acid decarboxylase 65(GAD_ 65 -Ab);
Autoantibody to protein tyrosine phosphatase-like proteins(IA2-Ab)
- From:
Chinese Journal of Practical Internal Medicine
2006;0(24):-
- CountryChina
- Language:Chinese
-
Abstract:
25 year).The patients were analyzed for the clinical characteristics.Autoantibodies to glutamic acid decarboxylase 65(GAD65-Ab),insulin(I-Ab)and autoantobodies to protein tyrosine phosphatase-like proteins(IA2-Ab)were assayed.HLA-DRB1,DQA1,DQB1 alleles(HLA-DRB1*03,*04,*09,*15,DQB1*0201,*0302,*0601,DQA1*0301,*0501)were typing by PCR-sequence specific primer(PCR-SSP).Results A little higher proportion of males,a longer duration of disease; a higher BMI and WHR characterized the adult-onset patients.The adults have a higher level of triglycerides and 120 min C-peptides than adolescent.The frequency and level of IA2-Ab of the adolescents were higher than adults(47.1% vs 15.1% and 0.46 U?mL~ -1 vs 0.07 U?mL~ -1 ,respectively,P
