Study on genomic imprinting of IGF2 gene.
- VernacularTitle:肺癌胰岛素样生长因子-2基因印迹的研究
- Author:
Qing JI
;
Yanfu WANG
;
Caihua ZHANG
- Publication Type:Journal Article
- Keywords:
Insulin-like growth factor 2;
Genomic imprinting;
Loss of imprinting;
Lung cancer
- From:
Chinese Journal of Practical Internal Medicine
2006;0(24):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of genomic imprinting of IGF2 gene in the development of lung cancer.Methods The IGF2 genomic imprinting was studied among 32 patients with lung cancer and the normal lung tissues by using PCR and RFLP.Results Twelve out of the 32 patients were informative(37.5),among whom 10 exhibited biallelic expression,i.e.,LOI(83.3).The matched normal tissues from 4 of these 10 patients also showed weak biallelic expression of IGF2.Conclusion The findings indicate that the loss of IGF2 imprinting is involved in the development of lung cancer.
