The Roles of Aquaporin-4 and Protein Kinase C in Brain Edema After Ischemic Stroke
- VernacularTitle:水通道蛋白4与蛋白激酶C在缺血性卒中后脑水肿中的作用
- Author:
Xinya LIU
;
Zhaohu CHU
- Publication Type:Journal Article
- Keywords:
aquaporin-4;
protein kinase C;
brain edema;
cerebral ischemia-reperfusion
- From:
International Journal of Cerebrovascular Diseases
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Aquaporin-4 (AQP4) is an important structural basis for water regulation and trans- portation in the central nervous system,which participates in physiopathological processes, such as cerebrospinal fluid reabsorption, osmotic regulation, and cerebral edema formation. Protein kinase C (PKC) exists in various cells, it catalyzes the phosphorylation of serine or threonine residues on various protein substrates.In recent years, studies have found that there is a certain correlation between the expressions of AQP4 and PKC after ischemic stroke.This article re- views the distribution,function,functional regulation of AQP4 and PKC,and their relations in ischemia-reperfusion.
