Effect of HQSM on PGI_2/TXA_2 in Blood Plasma of Myocardial Ischemia Rats with Pituitrin
- VernacularTitle:HQSM对垂体后叶素致心肌缺血大鼠血浆PGI_2/TXA_2的影响
- Author:
Guiyuan LV
;
Suhong CHEN
;
Xiaodong ZHANG
- Publication Type:Journal Article
- Keywords:
HQSM;
ischemic myocardium;
pituitrin;
disease models;
animal
- From:
Journal of Zhejiang Chinese Medical University
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To observe the effect of HQSM on PGI_2/TXA_2 in blood plasma of acute myocardial ischemia rats caused by injecting pituitrin. [Methods] 84 SD rats were divided into seven groups at random: normal control group,model control group,three HQSM groups(210mg/kg,150mg/kg,105mg/kg),Huangqi Shengmaiyin and DI’ao Xinxuekang. Intragastric administration was adopted once a day for 30 days.Acute myocardial ischemia model rat was established by injecting pituitrin from tail vein 1h after the last administration, and blood plasma was separated to be determined the activity of 6-Keto-PGF_ 1? and TXB_2, which is the metabolite of PGI_2 and TXA_2 in blood plasma of SD rats. [Results] Having been injected pituitrin,the activity of TXB2 upgraded while 6-Keto-PGF_ 1? /TXB_2 decreased(P
