Effect of Oxfenmino Hydrochloric Acid on Delayed Allergic Reaction in Mouse Induced by Dinitrofluorobenzene
- VernacularTitle:盐酸奥芬米洛对二硝基氟苯诱导小鼠迟发型变态反应的影响
- Author:
Xiaoping XU
;
Hui WANG
;
Minli CHEN
- Publication Type:Journal Article
- Keywords:
Oxfenmino hydrochloric acid;
Dinitrofluorobenzene(DNFB);
delayed allergic reaction;
mouse
- From:
Journal of Zhejiang Chinese Medical University
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To determine the effect of Oxfenmino hydrochloric acid on delayed allergic reaction in mouse. [ Method ] 120 ICR mice weighing 18~22g, half female and half male, were randomly and averagely divided into 6 groups according to weight:control group and model group (treated with distilled water at a dosage of 10ml/kg), three Oxfenmino hydrochloric acid groups (treated with Oxfenmino hydrochloric acid at a dosage of 10.0mg/kg, 5.0mg/kg and 2.5mg/kg respectively) and positive drug group (treated with CsA at a dosage of 15mg/kg); they were orally administered one time every day. After a continuous week of administration, all the groups were smeared evenly with 1%DNFB solution on the abdomen for allergy except the control group. Five days after allergy, 1%DNFB solution was smeared to right ear of all mice to stimulate the allergic reaction except that the control group was smeared with non-allergenic substance. 24 hours after attack, the auricle swelling, spleen index and thymus index in right mouse were determined. [ Result] Different dosages of Oxfenmino hydrochloric acid benefited to reduce auricle swelling, spleen index and thymus index in mouse with allergic reaction induced by DNFB at different degree. [ Conclusion] Oxfenmino hydrochloric acid can inhibit the delayed allergic reaction in mouse induced by DNFB and depress the ability of specific cell-mediated immunity.
