Relationship between oncosis and TNF-? in acute hepatic injury
- VernacularTitle:急性肝损伤中肝细胞胀亡与肿瘤坏死因子-?的关系
- Author:
Rongping LI
;
Chengshan REN
;
Yihui LI
- Publication Type:Journal Article
- Keywords:
D-galactosamine;
acute hepatic injury;
tumor necrosis factor-?;
oncosis, hepatocyte
- From:Journal of Third Military Medical University
2003;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of oncosis and TNF-? in D-galactosamine (D-GalN) induced acute hepatic injury. Methods Acute hepatic injury model was induced by D-GalN in 24 SD rats, and 12 rats served as control. At 4, 8, 12, 16, 20, 24 h after intraperitoneal injection of D-GalN, the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum, and the tumor necrosis factor-? (TNF-?) in liver tissue were measured. The pathological changes of liver and the oncosis of hepatocytes were observed by TEM. Results In acute hepatic injury, the levels of ALT, AST, TNF-? mRNA, OI were higher than that of control group (P
