Effect of indomethacin-loaded micelles on rheumatoid arthritis in rats
- VernacularTitle:吲哚美辛载药纳米胶束治疗大鼠实验性关节炎
- Author:
Xiaojing LI
;
Xiaohui LI
;
Jianxian ZHANG
- Publication Type:Journal Article
- Keywords:
indomethacin-loaded micelles;
adjuvant arthritis;
carrageenan-induced acute arthritis;
gastrointestinal stimulation
- From:Journal of Third Military Medical University
2003;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of indomethacin (IND)-loaded micelles on rheumatoid arthritis and its mechanism. Methods Freund’s-induced adjuvant arthritis and carrageenan-induced acute arthritis in SD rats were employed to evaluate the therapeutic effect of IND-loaded polymeric micelles after intraarticuar drug administration. Fifty-six SD rats were randomly divided to receive IND-loaded micelles at a dose of 4.5, 1.5, 0.5 mg/kg respectively, IND injection, oral administration of IND, blank PNIPAm/EAB-PPP-1 micelles at the 8~ th day once a day for a week after subcutaneous injection of 0.1 ml Freund’s into voix pedis of the right hind foot. The normal control rats took normal saline instead of Freund’s. There were 8 rats in each group. Results IND-loaded micelles could inhibit the swollen joint. No rats of intraarticular drug administration developed ulceration. Conclusion The sustained therapeutic efficacy could be achieved through intraarticular injection of IND-loaded micelles. Local delivery of IND can avoid severe gastrointestinal stimulation that frequently results from oral administration of IND.
