Human Papillomavirus16/18 Subgroup Infection in Laryngeal Squamous Cell Carcinomas
- VernacularTitle:人乳头状瘤病毒16/18感染与喉鳞状细胞癌关系
- Author:
Zhiling CHEN
;
Zhenghu WU
;
Xing GUO
;
Zuliang WU
- Publication Type:Journal Article
- Keywords:
Laryngeal neoplasms;
Carcinoma;
Squamous cell;
Papillomavirus;
Human;
In situ hybridization
- From:
Journal of Medical Research
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between human papillomavirus(HPV) 16/18 subgroup infection and laryngeal squamous cell carcinoma(LSCC).Methods The infection of HPV16/18 in 39 laryngeal carcinoma specimens and 10 vocal cord polyp specimens were detected by in situ hybridization. Results The positive rate of HPV16/18 expression in 39 laryngeal carcinoma specimens was 48.7%(19/39). The positive rate of HPV16/18 subgroup expression in 10 vocal cord polyps was 0(0/10) . Statistical test showed that HPV16/18 subgroup infection was significantly higher in LSCC than that in vocal cord polyps. No statistically association was observed among the frequency of HPV16/18 subgroup infection and TNM stages, degree of differentiation or lymph nodes metastases. Conclusions HPV 16/18 subgroup infection is associated with he pathogenesis of LSCC.
