Study on the Expression of MCP-1mRNA,MIP-1?mRNA and its Clinicopathological Significances in the Benign and Malignant Lesions of Mammary Gland
- VernacularTitle:乳腺良性恶病变组织MCP-1mRNA,MIP-1?mRNA表达及其临床病理意义
- Author:
Feng LONG
- Publication Type:Journal Article
- Keywords:
Mammary neoplasms;
Chemotactic factors;
Monocyte chemoattractant protein-1;
Macrophage imfammatory protein-1 alpha;
In situ hydridization
- From:
Journal of Medical Research
2006;0(11):-
- CountryChina
- Language:Chinese
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Abstract:
Objective To study on the expressions of MCP-1mRNA,MIP-1?mRNA and detect their clinicopathological significances in the benigr and malignant lesions of marnmary gland. Methods In situ hybridization was used for the detecting expressions of MCP-1mRNA and MIP-1?mRNA on the routinely paraffin-embedded sections of the specimen of the benign and malignant lesions of mammary gland. Results The positive rate of MCP-1mRNA,MIP-1?mRNA was significantly higher in the breast cancer than that in the benign lesion of mammary gland (62.5% vs 13.3%,?2=17.05,P2cm and with-metastasis of lymphnode in the breast cancer (P0.05). The closely positive correlation was found between the expression of MCP-1mRNA and MIP-1?mRNA in breast cancer (P
