Expression and implication of P-gp in colorectal cancer
- VernacularTitle:P糖蛋白在大肠癌中的表达及意义
- Author:
Weidong ZHU
;
Huijun TANG
;
Manyue ZHENG
- Publication Type:Journal Article
- Keywords:
P-glycoprotein;
Colorectal neoplasms
- From:
Chinese Journal of Primary Medicine and Pharmacy
2005;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression and significance of P-glycoprotein(P-gp) in colorectal carcinoma. Methods The expression patterns of P-gp in 48 patients with colorectal carcinoma were examined by immunohistochemistry SP mothod and were analyzed its correlation to clinic opathological features. Results The expression of P-gp was related to lympy node metastasis. Its expression was not related to sex and age of the patients, localization of the primary tumor, tumorsize, histological grade, localinvasion, distant metastasis and Duke's stage. Conclusion Detecting the expression of P-gp might play an important role in chemotherapy strategy of colorectal carcinoma.
