Progress of “Cocktail" probe substrates approaches
- VernacularTitle:“Cocktail”探针药物法的研究进展
- Author:
Ying LIU
;
Jianjie JIAO
;
Jianshi LOU
- Publication Type:Journal Article
- Keywords:
Cocktail;
cytochrome P450;
application
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
The method of simultaneous administration of several probe substrates is called “Cocktail" approaches. The objective of the article is to review the application of this technique in characterizing the activity of multiple drug-metabolizing enzymes and in clinical researches. This paper also shows Five-drug and Six-drug Cocktail set for evaluating in vivo activity of drug-metabolizing enzymes.
