Regulatory effect of indoleamine 2,3-dioxygenase on immune system
- VernacularTitle:吲哚胺2,3-二氧化酶与免疫系统功能调节
- Author:
Yunfeng FU
;
Yongxin REN
;
Yifu YANG
;
Jianping ZUO
- Publication Type:Journal Article
- Keywords:
indoleamine 2,3-dioxygenase;
tryptophan;
cell immune
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
The regulation of immune response is affected by several factors in order to maintain homeostasis.Indoleamine 2,3-dioxygenase(IDO) is a tryptophan-catabolizing enzyme expressed by different types of APC,including macrophages and dendritic cells.IDO activity leads to regulatory effects on T cells,which are mediated by tryptophan depletion in specific local tissue microenvironments,the production of proapoptotic metabolites,and inhibition of T-cell clone proliferation through regulatory T cells.IDO plays an important role in protecting the allogeneic fetus from rejection,the development of autoimmune diseases,allograft rejection,and cancer.So regulation of IDO activity may offer a novel drug-based strategy to treat immune-related diseases.
