Animal model of neuropathic pain and its application to research on pain mediated by P2X receptors
- VernacularTitle:神经病理痛动物模型及其在P2X受体介导痛觉研究中的应用
- Author:
Yun GAO
;
Shangdong LIANG
- Publication Type:Journal Article
- Keywords:
nuropathic pain;
ATP;
P2X receptors
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Neuropathic pain is the clinically common disease and does great harm to physical and mental health.Because its pathogenesis is still unclear and there aren′t effective therapeutic tools and the course of chronic pain lasts a long time,the study of neuropathic pain has become the hot spot and the focal point of pain research area.This article reviews various kinds of animal models of neuropathic pain,which can repeat neuropathic pain symptoms of mankind and may be effective ways to make research.By acting on P2X receptors,ATP is the signal of an important transmitting pain.By utilizing animal models of neuropathic pain,it shows that P2X receptors have an important role in the formation,transmission and regulation of pain and may be a new target of neuropathic pain therapy.
