The dynamic research of establishing fatty liver rats induced by high-fat diet
- VernacularTitle:高脂所致脂肪肝动物模型建立的动态研究
- Author:
Song LIU
;
Xiaocong LU
- Publication Type:Journal Article
- Keywords:
fatty liver;
hyperlipidemia;
animal model;
pathology;
rat
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To establish the fatty liver animal model induced by high-fat diet.Observe the dynamic variety of the hepatic steatosis in the different time.Finding out the ideal animal model-making time of hyperlipidemia and nonalcoholic fatty liver.Methods 50 wistar rats were fed with high-fat diet.The serum TG,TC,HDL,LDL,AST,and ALT were detected from 2 to 6 weeks.At the same time,we analyzed the hepatic steatosis situation. Results The rats developed hyperlipidemia and slight fatty liver after two weeks.In the following weeks,the serum lipid level and liver index kept rising.So did the amount of steatosis cells in liver tissue.The 3～4 weeks animal model had developed moderate fatty liver and the 5～6 weeks animal model had developed serious fatty liver.Liver fibrosis was detected in the 6 weeks animal model.Conclusions Feeding with high-fat diet,different phases of fatty liver had been developed in six weeks,and could been used for correlative pharmacological test.
