Study on 4977 bp deletion mutation of mitochondrial DNA in non-small lung cancer
- VernacularTitle:非小细胞肺癌线粒体基因组大片段缺失突变研究
- Author:
Jigang DAI
;
Yingbin XIAO
;
Jiaxin MIN
;
Guoqiang ZHANG
;
Mingzhang XIANG
;
Qiuping WU
;
Ke YAO
;
Renjie ZHOU
;
Zubin YU
- Publication Type:Journal Article
- Keywords:
mitochondrial DNA;
lung cancer;
deletion;
mutation
- From:Journal of Third Military Medical University
2003;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the 4 977 bp deletion of mitochondrial DNA in lung cancer, paraneoplastic tissue and normal lung tissue from non-lung cancer subjects and its significance in the development of cancer. Methods Lung cancer tissues and paraneoplastic tissues from 37 non-small lung cancer patients, and normal lung tissues from 20 patients without lung cancer were analyzed by long PCR technique. Results Mitochondrial DNA 4 977 bp deletion was detected in 54.1%(20/37) of lung cancer tissues, 59.5%(22/37) of paraneoplastic tissues and 30.0%(6/30) of normal lung tissues. The correlation between 4 977 bp deletion and age, smoking was present in our data. Conclusion Mitochondrial DNA 4 977 bp deletion, which may reflect the environmental and genetic influences during tumor progression, is not specific to lung cancer and unlikely to play an important role in carcinogenesis.
