Protective effect of supplementary taurine on spleen hematopoietic damage in left-half-body ionizing irradiated mice
- VernacularTitle:牛磺酸对~(60)Co?射线左半身照射小鼠脾脏造血功能的影响
- Author:
Long YANG
;
Xiangyu XU
;
Chengji LUO
;
Tianmin CHENG
- Publication Type:Journal Article
- Keywords:
ionizing radiation;
hematopoietic function;
spleen index;
spleen colony forming units;
taurine
- From:Journal of Third Military Medical University
2003;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of half-body ionizing radiation on the concentration of MDA, SOD in serum and the spleen index, CFU-S and the protective function of supplementary taurine (Tau) in half-body ionizing irradiated mice. Methods Kunming mice were randomly divided into 6 groups: normal control, total-body irradiation (TBI), total-body irradiation+Tau, left-half-body irradiation, half-body irradiation+Tau, and total-body shielding irradiation. The relevant indexes such as the spleen index, spleen colony forming units (CFU-S) were observed. The ionizing radiation was performed under ~ 60 Co ? ray with absorbed dose 8.0 Gy, dose rate 68.46 cGy/min. Taurine at dose of 500 mg/kg was injected intraperitoneally twice a day before irradiation, once 30 min before irradiation, and once 6 h after irradiation. Results In TBI group, the spleen index and CFU-S were decreased remarkably, MDA increased and SOD reduced in serum. The hematopoietic function of spleen was not improved by supplementary taurine (P
