Effect of Dihuang Yinzi on synaptophysin,extracellular regulated protein in hippocampus of aged rats
- VernacularTitle:中药地黄饮子对老龄大鼠海马SYP、ERK蛋白表达的影响
- Author:
Xigui WU
;
Rong HU
- Publication Type:Journal Article
- Keywords:
Dihuang Yinzi;
learning and memory;
brain aging;
SYP;
ERK
- From:Journal of Third Military Medical University
2003;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the function and mechanism of Dihuang Yinzi (DHYZ) in promoting learning and memory and delaying brain aging. Methods The Wistar rats aged 20 months were randomly assigned to receive oral administration of 6, 12, 18 g?kg~ -1 ?d~ -1 DHYZ, or 2 ml/d normal saline (control) for 30 d (n=12 in each group), then space memory was detected with Morris Water Maze, and expression of synaptophysin (SYP) and extracellular regulated protein (ERK) were measured by immunohistochemistry and Western blotting. Results Rats administrated with DHYZ showed shorter mean escape latency (P
