Expression of human telomerase reverse transcriptase hTERT,Ki-67 and p27~(kip1) in pheochromocytoma and their significance.
- VernacularTitle:人类端粒酶逆转录酶hTERT Ki-67及p27~(kip1)在嗜铬细胞瘤组织的表达及意义研究
- Author:
Jianling LI
;
Zuojie LUO
;
Yingfen QIN
- Publication Type:Journal Article
- Keywords:
Phaeochromocytoma;
Paraganglioma;
hTERT;
Ki-67;
p27~(kip1)
- From:
Chinese Journal of Practical Internal Medicine
2006;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of human telomerase reverse transcriptase(hTERT),Ki-67 and p27~(kip1) in pheochromocytoma and paraganglioma,and to evaluate whether the expression of hTERT,Ki-67 and p27~(kip1) could serve as diagnostic markers for predicting the biological behaviour of these tumours.Methods Expression of hTERT,Ki-67 and p27~(kip1) was determined by immunohistochemistry in 45 pheochromocytomas/paragangliomas(31 benign,7 suspected malignant and 7 malignant)and 9 normal adrenal medulla samples.Results The hTERT was expressed in 5/7 malignant tumors,5/7 suspected malignant tumours and 3/31 benign tumours.Malignant and suspected malignant tumors expressed more hTERT(P
