Intracranial germinoma:clinical analysis of 45 patients.
- VernacularTitle:颅内生殖细胞瘤45例临床分析
- Author:
Xiuling ZUO
;
Jingtao DOU
;
Yiming MU
- Publication Type:Journal Article
- Keywords:
Intracranial germinoma;
Radiotherapy
- From:
Chinese Journal of Practical Internal Medicine
2006;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the clinical characteristics of the patients with intracranial germinoma.Methods Medical records of 45 patients with intracranial germinoma between 1993 and 2005 were retrospectively reviewed.Results The study population consisted of 30 males and 15 females,ranging in age from 20 months to 56 years old.Nineteen patients' tumors(42.2%)were in sellar region,13(28.9%)in pine region.Twenty-four patients(53%)had headache,nausea and vomiting.Twenty patients(40%)had blurred vision and visual field damage.Seventeen patients(38%)had diabetes insipidus.Twelve patients(27%)had hypopituitarism.Image study showed lesions were high density in CT and long T1,T2 in MRI.The signal was enhanced equally by contrast medium.?-hCG level of serum and CSF was measured,4 of 6 patients' serum ?-hCG level was elevated.Among those 4,?-hCG level in 2 patients' CSF was increased.Twelve patients were diagnosed pathologically,and 11 patients were diagnosed with experimental radiation.Others were diagnosed by clinical manifestation and image study.Eleven patients accepted operation therapy.Most of patients were treated with radiotherapy and chemotherapy.Symptoms were relieved obviously.Conclusion Intracranial germinoma mainly affects male children and adolescents.Common location of lesions is suprasellar and pine.Main manifestations of intracranial germinoma are headache,nausea,vomiting,blurred vision,visual field damage and diabetes insipidus.Biochemical and image examination have significance to diagnosis.Radiotherapy is a common and effective treatment for intracranial germinoma.
