Effects of propofol pretreatment on S100? and neurosecretion enzyme in rat brain tissues with global cerebral ischemia-reperfusion
- VernacularTitle:异丙酚预处理对全脑缺血再灌注大鼠脑组织S100?和神经元特异性烯醇化酶的影响
- Author:
Guosheng GAN
;
Wei DUAN
;
Li JIANG
- Publication Type:Journal Article
- Keywords:
propofol;
reperfusion injury;
S100 proteins;
phosphopyruvate hydratase
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of propofol pretreatment on S100? and neurosecretion enzyme (NSE) of brain tissues with global cerebral ischemia-reperfusion in rat, and to evaluate the effects of propofol in protection of brain. Methods 30 SD male rats were randomly divided into 3 groups: sham operation group (group A, n=10); single cerebral ischemia-reperfusion group (group B, n=10); propofol pretreatment at 2h before ischemia group (group C, n=10), in which propofol (100mg/kg) was given intraperitoneally (ip) before ischemia. 24h after ischemia-reperfusion, the neuroethology scores were recorded and evaluated, and S100? and NSE in rat brain were determined. Results The neuroethology scores of group A were higher than those of group B (P
