Effects of ginsenoside Rg_1 on the expression of VEGF and HIF-1? in acute myocardial infarction in rat
- VernacularTitle:人参皂苷Rg_1对急性心肌梗死后VEGF和HIF-1?的作用
- Author:
Yan JIN
;
Guinan LIU
;
Xianyang ZHU
- Publication Type:Journal Article
- Keywords:
ginsenoside Rg_1;
myocardial infarction;
neovascularization;
vascular endothelial growth factor;
hypoxia inducible factor-1?
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the influence of ginsenoside Rg1 on angiogenesis and the expression of vascular endothelial growth factor (VEGF) and hypoxia inducible factor-1? (HIF-1?) in rat acute myocardium ischemia (AMI) in rat. Methods A murine model of AMI was reproduced. Wistar rats (n=104) were randomly divided into shamoperation group, AMI control group, low ginsenoside Rg1 group (1mg/kg) and high ginsenoside Rg1 group (5mg/kg). Microvascular density, VEGF protein, VEGF and HIF-1? mRNA were assessed at 3, 7, 10 and 14 days after operation. Results The values of VEGF and HIF-1? mRNA were increasing with the duration of ischemia and hypoxia, and positive relationship was found between the time of AMI and the expression of HIF-1? mRNA. Ginsenoside Rg1 enhanced the formation of angiogenesis (P
