The role of Kupffer cells in modulation of hepatic regeneration
- VernacularTitle:库普弗细胞在肝再生调控中的作用机制
- Author:
Jiye YIN
;
Yong ZHANG
;
Liangwen SONG
- Publication Type:Journal Article
- Keywords:
Kupffer cells;
hepatectomy;
cytokines;
liver regeneration
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To approach the role of Kupffer cell (KC) in regulation of liver regeneration after partial hepatectomy (PH). Methods Condition medium of kupffer cells (KCCM) was prepared and the role of KCCM in promoting rat primary hepatocytes proliferation was observed by MTT method. The PH animal model was reproduced in mice and the rate of liver regeneration was measured and the expression features of TNF-?, TGF-? and TGF-?_1 were determined by immunohistochemical methods after PH with KC depletion. Results KCCM could promote primary hepatocyte proliferation significantly (A=0.746?0.06) compared with control (A=0.536?0.06, P
