Endoscopic diagnosis of acute intestinal graft-versus-host disease following allogeneic bone marrow transplantation
- VernacularTitle:骨髓移植术后急性肠道移植物抗宿主病内镜及病理学诊断研究
- Author:
Zhifeng WANG
;
Shanshan ZHANG
;
Pengyan NI
- Publication Type:Journal Article
- Keywords:
Gastrointestinal graft-versus-host disease;
Endoscopy;
Pathology
- From:
Chinese Journal of Practical Internal Medicine
2006;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective At present study,we sought to further define the significance of endoscopic and pathological findings in the diagnosis of acute intestinal GVHD.Methods The clinical、endoscopic and pathological data in 23 patients with proven acute intestinal GVHD were retrospectively reviewed.Results The endoscopic features of the ileum and colon varied from being grossly normal、loss of vascular markings、diffuse mucosal erythema、edema and friability to erosion、ulceration、mucosal sloughing and bleeding.Pathological findings included crypt epithelial cell apoptosis and dropout、crypt destruction and variable lymphocytic infiltration of epithelium and lamina propria.Conclusion Endoscopic and pathological evaluation of the ileum and colon can be used to diagnose acute intestinal GVHD.Endoscopy may play a significant role in establishing early diagnosis for acute intestinal GVHD in patients following allogeneic BMT,but pathological evaluation of the ileal and colonic mucosa is needed to confirm the final diagnosis.
