GP130 expression during cardiac hypertrophy induced by pressure overload in rats and its response to intervention of Benazepril
- VernacularTitle:大鼠压力超负荷心肌糖蛋白130表达及贝那普利干预研究
- Author:
Feng JIN
;
Longgui LI
;
Zhaohua GEN
;
Hongting ZHENG
- Publication Type:Journal Article
- Keywords:
cardiac hypertrophy;
GP130;
cardiotrophin-1;
Benazepril
- From:Journal of Third Military Medical University
2003;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of GP130 expression in rats with pressure overload-induced cardiac hypertrophy, and the effect of Benazepril on GP130 expression and the concerned cardiac hypertrophy. Methods Two weeks after the Wistar rat model of pressure overload was established by constriction of abdominal aorta, the survived rats were randomly divided into hypertrophy group (LVH, n=7) and Benazepril intervention group (Ben, n=7, 1 mg?kg -1 ?d -1 Benazepril orally for 3 weeks). A sham-operation group (Sham, n=7) was set up as control. Blood pressure and left ventricular mass index (LVMI) were investigated at 3th week after model establishment. AngⅡ level in myocardium was measured by radioimmunoassay. The protein level of GP130 in cardiomyocytes was determined by immunohistochemistry. Results As compared with the Sham group, blood pressure and LVMI increased significantly (P
