Effect of environmental enrichment at different development stages on learning and memory abilities in hypoxia-ischemic brain injured postnatal rats
- VernacularTitle:脑发育不同阶段丰富环境刺激对缺氧缺血性脑损伤大鼠学习记忆的影响
- Author:
Zhaoxia PU
;
Congmin ZHAO
;
Liqun LU
- Publication Type:Journal Article
- Keywords:
hypoxia-ischemic brain damage;
environmental enrichment;
early intervention;
learning and memory
- From:Journal of Third Military Medical University
2003;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of environmental stimulation at different stages of development on postnatal rats with hypoxia-ischemic brain injury (HIBI). Methods HIBI postnatal SD rats models were established by dissecting and ligating the left common carotid artery, and after 2 h of recovery, exposing to 8% oxygen-92% nitrogen gas mixture for 2 h. The HIBI rats were randomly divided into early intervention groups, late intervention group, non-intervention group. Intervention group were kept in enriched environment before or after weaning for 20 d. Non-intervention group and control group were kept in a standard environment. Space learning and memory were tested with Morris water maze. Results The ability of space learning and memory in early intervention group was better than that in late intervention group (P
