Expression of heparanase in ovarian cancer and its clinical significance
- VernacularTitle:乙酰肝素酶在卵巢癌组织中的表达及其临床意义
- Author:
Jing HAN
;
Ying YANG
;
Ping YAN
;
Yan LIAN
- Publication Type:Journal Article
- Keywords:
ovarian cancer;
immunohistochemistry;
heparanase;
prognosis
- From:Journal of Third Military Medical University
2003;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the relationship of heparanase expression and age, clinicopathological features and prognosis of ovarian cancer patients. Methods Forty-one ovarian cancer specimens, from the patients admitted to the 3 hospitals of our university during the period of Jan 2003 to Nov 2005, were of serous carcinoma (22 cases) and mucous carcinoma (10 cases) and other types (9 cases), of which 16 were well and moderately differentiated and 25 poorly differentiated. Ten specimens of normal ovarian tissues were taken as normal controls. The heparanase expression was detected in all specimens and its relationship with histologic type, differentiation, FIGO stage and prognosis of the ovarian cancer was analyzed. Results The positive rate of heparanase expression was 80.48% in ovarian cancer tissues and 10.00% in normal ovarian tissues (P
