Effect of dexamethasone on eosinophil apoptosis and expression of interleukin-5 mRNA and interleukin-10 mRNA in bronchoalveolar lavage fluid of asthmatic guinea pig
- VernacularTitle:地塞米松对哮喘豚鼠气道白介素-5、白介素-10 mRNA表达及嗜酸性粒细胞凋亡的影响
- Author:
Guangwei LUO
;
Jiemin SUN
;
No WUHAN
- Publication Type:Journal Article
- Keywords:
asthma;
dexamethasone;
eosinophils;
apoptosis;
interleukin
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of dexamethasone on eosinophil apoptosis and expression of interleukin-5 mRNA and interleukin-10 mRNA in bronchoalveolar lavage fluid (BALF) of asthmatic guinea pig. METHODS: 30 Hartley male guinea pigs were divided into 3 groups randomly: dexamethasone group, asthma group and control group. The EOS apoptosis, IL-5 mRNA and IL-10 mRNA expressions were measured by the techniques of TUNEL and RT-PCR. RESULTS: The EOS in BALF of dexamethasone group decreased prominently compared with the asthma group (P
