Alteration of pain related factors levels after Yunke and ~(153)Sm-EDTMP treatment in patients with painful skeletal metastases
- VernacularTitle:云克与~(153)钐-乙二胺四甲基膦酸对骨转移癌患者骨痛及疼痛因子的影响
- Author:
Guanghua CHENG
;
Yunhai DAI
;
Jun YANG
- Publication Type:Journal Article
- Keywords:
~(99)Tc-MDP;
~(153)Sm-EDTMP;
skeletal metastases;
ET;
CGRP;
TXB_2;
6-k-PGF_(1?)
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To comparatively analyze the pain related factors levels and therapeutic response in patients treated with ~(99)Tc-MDP and ~(153)Sm-EDTMP for painful skeletal metastases. METHODS: Plasma endothelin (ET), calcitonin gene-related peptide (CGRP), thromboxane B_2 (TXB_2) and 6-keto-prostaglandin F_ 1? (6-k-PGF_ 1? ) levels were analyzed in 93 patients with painful skeletal metastases prior and 3 months after treatment. 55 cases were just treated with 153 Sm-EDTMP (group A); 19 cases were treated only with 99 Tc-MDP (group B); and 19 cases were treated with both 153 Sm-EDTMP and 99 Tc -MDP (group C). RESULTS: 69.1 %, 73.7 % and 89.5 % of the patients were experienced pain relief 3 months after treatment in groups A, B and C, respectively. Comparative analysis shows that: ET and 6-k-PGF_ 1? levels increased significantly 3 months after treatment in all patients (P
