Expression of complement regulatory proteins C_1-INH and CD46 in nasal mucosa of allergic rhinitis rats
- VernacularTitle:变应性鼻炎大鼠鼻黏膜中补体调节蛋白C_1-INH和CD46的表达
- Author:
Juntian LANG
- Publication Type:Journal Article
- Keywords:
complement regulatory protein;
C_1-INH;
CD46;
rhinitis,allergic
- From:
Academic Journal of Second Military Medical University
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the expression of complement regulatory proteins(CRPs) C_1-INH,MCP(CD46) in the nasal mucosa of allergic rhinitis rats and to study the role of CRPs in the pathogenesis of allergic rhinitis.Methods: Nine healthy SD rats were sensitized and intranasally challenged with ovalbumin and Al(OH)_3(as supplement) to establish allergic rhinitis models and another 9 SD rats treated with saline were taken as control.The nasal mucosa in respiratory area of both groups was obtained.Then Western blotting was performed to investigate the expression levels of C_1-INH and CD46.Results: Western blotting showed that both C_1-INH and CD46 had been detected in rat nasal mucosa.Expression level of CD46 in the nasal mucosa of allergic rhinitis was significantly higher than that in control rats(P
